Five best friends from college (Scarlett Johansson, Kate McKinnon, Jillian Bell, Ilana Glazer, and Zoë Kravitz) reunite 10 years later for a wild bachelorette weekend in Miami. During their hard partying, they accidentally kill a male stripper. Amidst the craziness of trying to conceal their deed, they are ultimately brought closer together when it matters most.