Owen Wilson has signed on to voice the rascally Great Dane "Marmaduke," Fox's adaptation of the long-running comic strip.

Wilson's boarding is the last piece of the puzzle for the live-action/CG movie, which has shades of Fox's surprise smash "Marley & Me" and follows a family named the Winslows who move from Kansas to Orange County with their dog Marmaduke, a slobbery pooch who creates chaos wherever he goes.

In adapting the strip created in 1954 by Brad Anderson and Phil Leeming, the script by Tim Rasmussen and Vince Di Meglio sees Marmaduke navigate a volatile Mutts vs. Pedigrees turf war, woo the purebred of his dreams and overcome a fall from grace.

Judy Greer, Lee Pace and William H. Macy play the humans, while Fergie, Emma Stone, George Lopez, Christopher Mintz-Plasse, Steve Coogan, Damon Wayans, Marlon Wayans supply the voices.

Tom Dey is directing, and John Davis is producing the family comedy, which has a June 2010 release date.

Wilson, repped by UTA, starred opposite a rambunctious lab in Fox's "Marley" and did voice work in the studio's upcoming animated Wes Anderson pic "The Fantastic Mr. Fox." He is following the steps of Bill Murray, who voiced another famous comic strip animal, the lasagna-loving cat "Garfield," also from Fox.