Meet Dave, an alien spaceship disguised as a human; Eddie Murphy to be exact. The tiny beings inside him are on a mission to Earth in order to search for an orb that was knocked out of orbit. Lead by the Captain, Dave must find a way to save their planet from destruction. Things become somewhat difficult when the human environment begins to affect the crew members, forcing emotion out of Dave as well, causing him to fall in love with Gina (Elizabeth Banks). Now the Captain must decide between the mission and the Earth. Oh, there is comedy involved as well.