Kate Holbrook (Tina Fey) has put of having a baby in exchange for a successful career. At 37 she is desperate for a baby and has tried everything including artificial insemination and adoption only to find that a single career woman has almost no chance of adopting and that she does in fact have a T shaped uterus which makes it impossible for her to become pregnant. When all else fails she finds herself a surrogate mother to carry her child for her. Enter Angie Ostrowiski (Amy Poehler), the least likely candidate to carry another persons child. The two women find themselves living together in Kate’s apartment as a female version of the Odd Couple and Kate must balance work, her love life, and looking after Angie.